Pub. Date : 2018 Nov 1
PMID : 30213730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, ATO-treated U937 cells showed ROS-mediated inhibition of TET2 transcription, leading to downregulation of FOXP3 expression and in turn, suppression of FOXP3-mediated activation of Lyn and Akt. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Further, ATO-induced Akt inactivation promoted GSK3beta-mediated degradation of MCL1. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Transfection of constitutively active Akt expression abrogated ATO-induced MCL1 downregulation. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Thus, our data suggest that ATO induces mitochondria-mediated apoptosis in U937 cells through its suppressive effect on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 transcription and protein stabilization. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |