Title : Computer-based search for steroid and DNA binding sites on estrogen and glucocorticoid receptors.

Pub. Date : 1986 Aug 29

PMID : 3021126






2 Functional Relationships(s)
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1 Others have proposed that the segment on the ER and GR that is nearest their amino terminus (e.g. residues 173-250 of the ER) is part of their DNA binding domain and that the other two similar segments on each receptor, which are closer to their carboxy terminus, are part of their steroid binding domain. Steroids nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 First, an Align computer analysis indicates that residues 323-395 of the ER and residues 570-612 of the GR contain a region that is similar to a part of the alpha-subunit of the (Na+ + K+)ATPase that is hypothesized to bind the steroid ouabain. Steroids nuclear receptor subfamily 3 group C member 1 Homo sapiens