Pub. Date : 2018 Dec 1
PMID : 30207165
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously showed the pathogenic effects of MPO-ANCA that activate MPO to trigger an oxidative burst mainly through HOCl production, contributing to endothelial injury and lung fibrosis. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 2 | We previously showed the pathogenic effects of MPO-ANCA that activate MPO to trigger an oxidative burst mainly through HOCl production, contributing to endothelial injury and lung fibrosis. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 3 | MPA patients" sera displayed higher HOCl production by MPO ( P < 0.001), higher AOPP ( P < 0.001) and thiol ( P < 0.01) levels, compared with healthy subjects. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 4 | Our findings suggest that HOCl production by activated MPO could contribute to the very early stage of glomerulonephritis, whereas thiol may exert a protective effect against the development of renal vasculitis and glomerulosclerosis. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |