Title : Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels.

Pub. Date : 2018 Sep 11

PMID : 30206371






4 Functional Relationships(s)
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Protein Name
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1 Phagocytes destroy ingested microbes by producing hypochlorous acid (HOCl) from chloride ions (Cl-) and hydrogen peroxide within phagolysosomes, using the enzyme myeloperoxidase. Hypochlorous Acid myeloperoxidase Homo sapiens
2 Phagocytes destroy ingested microbes by producing hypochlorous acid (HOCl) from chloride ions (Cl-) and hydrogen peroxide within phagolysosomes, using the enzyme myeloperoxidase. Hypochlorous Acid myeloperoxidase Homo sapiens
3 As myeloperoxidase is needed for HOCl production, non-myeloid cells are considered incapable of producing HOCl. Hypochlorous Acid myeloperoxidase Homo sapiens
4 Inhibition is also reversed in the presence of 4-aminobenzoic hydrazide, a myeloperoxidase inhibitor, suggesting epithelial cells have a peroxidase to convert Cl- to HOCl. Hypochlorous Acid myeloperoxidase Homo sapiens