Pub. Date : 2019 Jan 8
PMID : 30197302
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300-mediated acetylation of the mTORC1 regulator, Raptor, at K1097. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300-mediated acetylation of the mTORC1 regulator, Raptor, at K1097. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 7 | Leu metabolism and consequent mTORC1 activity are regulated by intermediary enzymes. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 8 | These results provide a direct mechanism for mTORC1 regulation by Leu metabolism. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |