Pub. Date : 2018 Sep 15
PMID : 30195874
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular mechanism and cytotoxicity of allicin and all-trans retinoic acid against CD44+ versus CD117+ melanoma cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 2 | To clarify this mechanism, we determined the sensitivity to ATRA, allicin and allicin/ATRA in CD44+ and CD117+ melanoma cell subpopulations. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 3 | RESULTS: Here, we demonstrated that CD44+ melanoma cells were more resistant to allicin and ATRA than CD117+ cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 4 | The combination treatment with allicin and ATRA significantly reduced the IC50 value obtained for ATRA alone in CD44+ melanoma cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 5 | The combination treatment with allicin and ATRA significantly reduced the IC50 value obtained for ATRA alone in CD44+ melanoma cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 6 | In CD44+ cells, the IC50 value of ATRA was 37.43 +- 0.54, while the IC50 value of allicin/ATRA treatment was 17.53 +- 0.2 microM. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 7 | The combination treatment caused the inhibition of CD44+ and CD117+ melanoma cells at the S phases compared to ATRA alone. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 8 | Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 9 | Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 10 | In contrast, ATRA and the combination treatment significantly increased MMP-9 gene expression in CD44+ cells. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |
| 11 | CONCLUSION: Overall, our results indicate that allicin reinforces the ATRA-mediated inhibitory effects on CD44+ and CD117+ melanoma cells and may provide a new approach for the treatment of malignant melanoma. | Tretinoin | CD44 molecule (Indian blood group) | Homo sapiens |