Pub. Date : 2018 Sep 6
PMID : 30189852
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1beta-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 2 | BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 3 | BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 4 | BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 5 | BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 6 | Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 7 | Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |
| 8 | CONCLUSIONS: Our data indicate that EPA elicited neuroprotection toward IL-1beta-induced cell damage and BDNF decrease and that its effects potentially occurred via the Akt/CREB signaling pathway. | Eicosapentaenoic Acid | interleukin 1 beta | Rattus norvegicus |