Pub. Date : 2018 Dec
PMID : 30182339
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In silico screening for ERalpha down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERalpha-expressing breast cancer cells. | Thioridazine | estrogen receptor 1 | Homo sapiens |
| 2 | In silico screening for ERalpha down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERalpha-expressing breast cancer cells. | Thioridazine | estrogen receptor 1 | Homo sapiens |
| 3 | RESULTS: We found that mitoxantrone and thioridazine induced ERalpha downmodulation and prevented MCF-7 BC cell proliferation. | Thioridazine | estrogen receptor 1 | Homo sapiens |
| 4 | Thioridazine also reduced the ERalpha content and prevented cell proliferation in primary, Tam-resistant and genome-edited Y537S ERalpha expressing BC cells. | Thioridazine | estrogen receptor 1 | Homo sapiens |
| 5 | Thioridazine also reduced the ERalpha content and prevented cell proliferation in primary, Tam-resistant and genome-edited Y537S ERalpha expressing BC cells. | Thioridazine | estrogen receptor 1 | Homo sapiens |
| 6 | CONCLUSIONS: We suggest that modulation of the intracellular ERalpha concentration in BC cells can be exploited in in silico screens to identify anti-BC drugs and uncover a re-purposing opportunity for thioridazine in the treatment of primary and metastatic ET resistant BCs. | Thioridazine | estrogen receptor 1 | Homo sapiens |