Pub. Date : 2018 Sep 26
PMID : 30180543
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nevertheless, while TAML/H2O2 rapidly degrades the drug propranolol, a micropollutant (MP) of broad concern, propranolol is shown to inhibit its own destruction under concentration conditions amenable to kinetics studies ([propranolol] = 50 muM). | Propranolol | latexin | Homo sapiens |
| 2 | Nevertheless, while TAML/H2O2 rapidly degrades the drug propranolol, a micropollutant (MP) of broad concern, propranolol is shown to inhibit its own destruction under concentration conditions amenable to kinetics studies ([propranolol] = 50 muM). | Propranolol | latexin | Homo sapiens |
| 3 | However, based on the measured kI and calculated equilibrium constant K for propranolol-TAML binding, it is possible to project the impact on kI of reducing [propranolol] from 50 muM to the ultradilute regime typical of MP contaminated waters (<=2 ppb, <=7 nM for propranolol) where inhibition nearly vanishes. | Propranolol | latexin | Homo sapiens |
| 4 | However, based on the measured kI and calculated equilibrium constant K for propranolol-TAML binding, it is possible to project the impact on kI of reducing [propranolol] from 50 muM to the ultradilute regime typical of MP contaminated waters (<=2 ppb, <=7 nM for propranolol) where inhibition nearly vanishes. | Propranolol | latexin | Homo sapiens |
| 5 | However, based on the measured kI and calculated equilibrium constant K for propranolol-TAML binding, it is possible to project the impact on kI of reducing [propranolol] from 50 muM to the ultradilute regime typical of MP contaminated waters (<=2 ppb, <=7 nM for propranolol) where inhibition nearly vanishes. | Propranolol | latexin | Homo sapiens |
| 6 | Projecting from 50 muM to higher concentrations, propranolol completely inhibits its own oxidation before reaching mM concentrations. | Propranolol | latexin | Homo sapiens |