Title : Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease.

Pub. Date : 2018 Dec

PMID : 30171891






1 Functional Relationships(s)
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1 Here we describe an engineered htt exon1 analog featuring a short polyQ sequence that nonetheless quickly forms amyloid fibrils and causes HD-like toxicity in rat neurons and Drosophila. polyglutamine huntingtin Rattus norvegicus