Pub. Date : 2018 Dec
PMID : 30171891
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additional modifications within the polyQ segment produce htt exon1 analogs that populate only spherical oligomers and are non-toxic in cells and flies. | polyglutamine | huntingtin | Drosophila melanogaster |
| 2 | Furthermore, in mixture with expanded-polyQ htt exon1, the latter analogs in vitro suppress amyloid formation and promote oligomer formation, and in vivo rescue neurons and flies expressing mhtt exon1 from dysfunction and death. | polyglutamine | huntingtin | Drosophila melanogaster |
| 3 | Thus, in our experiments, while htt exon1 toxicity tracks with aggregation propensity, it does so in spite of the toxic construct"s possessing polyQ tracts well below those normally considered to be disease-associated. | polyglutamine | huntingtin | Drosophila melanogaster |