Title : IL-22 Down-Regulates Cx43 Expression and Decreases Gap Junctional Intercellular Communication by Activating the JNK Pathway in Psoriasis.

Pub. Date : 2019 Feb

PMID : 30171832






1 Functional Relationships(s)
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1 The IL-22-induced down-regulation of Cx43 expression and decrease in GJIC can be significantly blocked by the JNK inhibitor SP600125 and by the overexpression of IL-22RA2 (which specifically binds to IL-22 and inhibits its activity), but not by the NF-kappaB inhibitor BAY11-7082, in HaCaT cells. pyrazolanthrone interleukin 22 Homo sapiens