Title : Oxidation of chloride and thiocyanate by isolated leukocytes.

Pub. Date : 1986 Jul 25

PMID : 3015901






4 Functional Relationships(s)
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Protein Name
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1 Under conditions similar to those in plasma (0.14 M Cl-, 0.02-0.12 mM SCN-), myeloperoxidase catalyzed the oxidation of Cl- to hypochlorous acid (HOCl), which reacted with ammonia and amines to yield chloramines. thiocyanate myeloperoxidase Homo sapiens
2 Under conditions similar to those in saliva and the surface of the oral mucosa (20 mM Cl-, 0.1-3 mM SCN-), myeloperoxidase catalyzed the oxidation of SCN- to OSCN-, which accumulated in the medium to concentrations of up to 40-70 microM. thiocyanate myeloperoxidase Homo sapiens
3 Under conditions similar to those in saliva and the surface of the oral mucosa (20 mM Cl-, 0.1-3 mM SCN-), myeloperoxidase catalyzed the oxidation of SCN- to OSCN-, which accumulated in the medium to concentrations of up to 40-70 microM. thiocyanate myeloperoxidase Homo sapiens
4 OSCN- was produced when SCN- was 0.1 mM or higher and myeloperoxidase, eosinophil peroxidase, or lactoperoxidase was added. thiocyanate myeloperoxidase Homo sapiens