Pub. Date : 2018 Nov 15
PMID : 30125880
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At the pore diameter of about 65 nm, CYP3A4 shows the highest affinity to testosterone with the Michaelis-Menten constant (Kmapp) of 110.70 +- 18 muM and the relatively higher reaction rate with the Imax value of 11.85 +- 1.20 nA, which is due to the maintained native configuration and larger amount of immobilized enzyme. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Furthermore, the constructed CYP3A4/PNGF-1 nanoreactor is successfully applied to the metabolism of three steroid hormones (testosterone, estrone and progesterone), and the order of the calculated Kmapp values is consistent with literature. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |