Title : Effect of various blockers of arachidonic acid metabolism on release of beta-endorphin- and adrenocorticotropin-like immunoreactivity induced by phospholipase A2 from rat adenohypophysis in vitro.

Pub. Date : 1986

PMID : 3012392






2 Functional Relationships(s)
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1 However, NDGA or ETYA inhibited phospholipase A2-induced beta-End-IR release. Masoprocol phospholipase A2 group IB Rattus norvegicus
2 These data are consistent with the view that phospholipase A2 releases endogenous arachidonic acid which is transformed into products which stimulate ACTH and beta-endorphin release from the corticotrophs; the metabolizing enzyme (possibly a lipoxygenase or epoxygenase) is sensitive to NDGA and especially to ETYA. Masoprocol phospholipase A2 group IB Rattus norvegicus