Pub. Date : 1986 Feb 15
PMID : 3010956
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets. | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 2 | Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 3 | Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 4 | Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 5 | In addition, vasopressin elicited a transient depletion of [glycerol-3H]PtdIns and accumulation of [glycerol-3H]PtdA. | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 6 | The effects of vasopressin on phosphoinositide metabolism were concentration-dependent, with half maximal [32P]PtdA formation occurring at 30 +/- 15 nM-vasopressin. | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 7 | The effects of vasopressin on phosphoinositide metabolism were concentration-dependent, with half maximal [32P]PtdA formation occurring at 30 +/- 15 nM-vasopressin. | Phosphatidylinositols | arginine vasopressin | Homo sapiens |
| 8 | These results indicate that vasopressin-induced human platelet activation is initiated by combination with specific V1 receptors on the platelet, and that the sequelae of receptor occupancy (stimulation of phosphoinositide metabolism and elevation of [Ca2+]i) are equally susceptible to inhibition by receptor antagonists and by receptor desensitization. | Phosphatidylinositols | arginine vasopressin | Homo sapiens |