Title : Overcoming resistance in non-small-cell lung cancer: A practical lesson for the medicinal chemist.

Pub. Date : 2018 Oct

PMID : 30101528






2 Functional Relationships(s)
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1 Traditional chemotherapy is marginally effective against this form, and erlotinib and gefitinib were introduced as first-line treatments based on the observation that the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is mutated in several cases and, thus, represents a druggable target. Gefitinib ret proto-oncogene Homo sapiens
2 Traditional chemotherapy is marginally effective against this form, and erlotinib and gefitinib were introduced as first-line treatments based on the observation that the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is mutated in several cases and, thus, represents a druggable target. Gefitinib ret proto-oncogene Homo sapiens