Title : Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.

Pub. Date : 2019 Jan

PMID : 30096040






3 Functional Relationships(s)
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1 Although the Km of arachidonic acid for acetylated COX-2 was ~3-fold lower than for uninhibited COX-2, the catalytic efficiency for PG formation by the acetylated enzyme was reduced 10-fold due to a concomitant decrease in Vmax. Arachidonic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Although the Km of arachidonic acid for acetylated COX-2 was ~3-fold lower than for uninhibited COX-2, the catalytic efficiency for PG formation by the acetylated enzyme was reduced 10-fold due to a concomitant decrease in Vmax. Arachidonic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 We conclude that acetylation of Ser530 in COX-2 not only triggers formation of 15 R-HETE but also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxide. Arachidonic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens