Title : Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells.

Pub. Date : 2018 Oct

PMID : 30092417






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment of HUVECs with TCDD (AhR inducer) resulted in a significant induction of AHR target genes CYP1A1, CYP1B1 and NQO1. Polychlorinated Dibenzodioxins cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Western blot analysis confirmed CYP1B1 induction in TCDD-treated HUVECs, but not in the simvastatin group. Polychlorinated Dibenzodioxins cytochrome P450 family 1 subfamily B member 1 Homo sapiens
3 Moreover, HUVEC exposure to TCDD resulted in induction of CYP1A1/CYP1B1 enzymatic activity. Polychlorinated Dibenzodioxins cytochrome P450 family 1 subfamily B member 1 Homo sapiens