Title : Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss.

Pub. Date : 2018 Sep 13

PMID : 30091915






1 Functional Relationships(s)
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1 We recently demonstrated that the pharmacologic inhibition with kenpaullone or genetic deletion of CDK2 preserved hearing function in animal models treated with cisplatin, which suggests that CDK2 is a promising therapeutic target to prevent cisplatin-induced ototoxicity. kenpaullone cyclin-dependent kinase 2 Mus musculus