Title : Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

Pub. Date : 2019 Jan

PMID : 30085883






4 Functional Relationships(s)
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1 We used an oral treatment with dimethyl fumarate and the HCAR2 endogenous ligand beta-hydroxybutyrate (BHB) in wild-type (WT) and HCAR2-null mice. 3-Hydroxybutyric Acid hydroxycarboxylic acid receptor 2 Mus musculus
2 We used an oral treatment with dimethyl fumarate and the HCAR2 endogenous ligand beta-hydroxybutyrate (BHB) in wild-type (WT) and HCAR2-null mice. 3-Hydroxybutyric Acid hydroxycarboxylic acid receptor 2 Mus musculus
3 This effect was completely lost in the HCAR2-null mice after a 2-d starvation protocol, in which the BHB reached the concentration able to activate the HCAR2-reduced tactile allodynia in female WT mice, but not in the HCAR2-null mice. 3-Hydroxybutyric Acid hydroxycarboxylic acid receptor 2 Mus musculus
4 This effect was completely lost in the HCAR2-null mice after a 2-d starvation protocol, in which the BHB reached the concentration able to activate the HCAR2-reduced tactile allodynia in female WT mice, but not in the HCAR2-null mice. 3-Hydroxybutyric Acid hydroxycarboxylic acid receptor 2 Mus musculus