Title : Insulin inhibits autophagy signaling independent of counter-regulatory hormone levels, but does not affect the effects of exercise.

Pub. Date : 2018 Aug 2

PMID : 30070610






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1 In a separate series of experiments, we show that insulin stimulates ULK1 phosphorylation at Ser757 (inhibitory site) in both hypoglycemic and euglycemic conditions, suggesting that counter-regulatory hormones (such as epinephrine, norepinephrine, growth hormone and glucagon) have limited effects on autophagy signaling in human skeletal muscle. Glucagon insulin Homo sapiens