Pub. Date : 2018 Jul 31
PMID : 30067985
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359. | Proline | tumor protein p53 | Homo sapiens |
| 2 | Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain. | Proline | tumor protein p53 | Homo sapiens |
| 3 | Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain. | Proline | tumor protein p53 | Homo sapiens |
| 4 | Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. | Proline | tumor protein p53 | Homo sapiens |
| 5 | Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. | Proline | tumor protein p53 | Homo sapiens |
| 6 | Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. | Proline | tumor protein p53 | Homo sapiens |
| 7 | Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. | Proline | tumor protein p53 | Homo sapiens |