Pub. Date : 2018 Oct
PMID : 30066906
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously reported that the combined inhibition of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) led to an increased antitumor activity of docetaxel in CRPC. | Docetaxel | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | We have previously reported that the combined inhibition of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) led to an increased antitumor activity of docetaxel in CRPC. | Docetaxel | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | The enhanced expression of EGFR and COX-2 was observed in docetaxel-resistant CRPC relative to the parental cell lines. | Docetaxel | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | In conclusion, the combined inhibition of EGFR and COX-2 by gefitinib and celecoxib may overcome docetaxel resistance in human CRPC. | Docetaxel | prostaglandin-endoperoxide synthase 2 | Homo sapiens |