Pub. Date : 2018 Oct 1
PMID : 30055191
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reversal of Sp1 transactivation and TGFbeta1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 2 | Moreover, H2S incubation reversed nickel-stimulated TGFbeta1/SMAD1 signal and blocked TGFbeta1-initiated expressions of alphaSMA and fibronectin. | Nickel | transforming growth factor beta 1 | Homo sapiens |
| 3 | Nickel inhibited the interaction of Sp1 with CSE promoter but strengthened the binding of Sp1 with TGFbeta1 promoter, which was reversed by exogenously applied NaHS. | Nickel | transforming growth factor beta 1 | Homo sapiens |