Pub. Date : 2018 Jul 3
PMID : 30038711
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RET fusions observed in lung and colorectal cancers are sensitive to ponatinib. | ponatinib | ret proto-oncogene | Homo sapiens |
| 2 | Identifying ponatinib as the most potent RET inhibitor tested, we used ponatinib to gauge therapeutic responsiveness in RET fusion-positive patient-derived xenograft (PDX) models. | ponatinib | ret proto-oncogene | Homo sapiens |
| 3 | By comparing ponatinib activity in RET fusion-positive and RET fusion-negative PDX models alongside a standard of care chemotherapeutic agent, we show that RET fusions in colorectal tumors are therapeutically responsive to RET inhibition. | ponatinib | ret proto-oncogene | Homo sapiens |