Pub. Date : 2018 Jul 23
PMID : 30038412
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Conversely, loss of UBR5 increases HTT levels and triggers polyQ-expanded aggregation in HD-iPSCs. | polyglutamine | ubiquitin protein ligase E3 component n-recognin 5 | Homo sapiens |
| 2 | Moreover, UBR5 knockdown hastens polyQ-expanded aggregation and neurotoxicity in invertebrate models. | polyglutamine | ubiquitin protein ligase E3 component n-recognin 5 | Homo sapiens |
| 3 | Notably, UBR5 overexpression induces polyubiquitination and degradation of mutant HTT, reducing polyQ-expanded aggregates in HD-cell models. | polyglutamine | ubiquitin protein ligase E3 component n-recognin 5 | Homo sapiens |