Title : Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.

Pub. Date : 2018 Jul 12

PMID : 30034590






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo. Pyridones ret proto-oncogene Homo sapiens