Title : Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4.

Pub. Date : 2020 Apr

PMID : 30032721






2 Functional Relationships(s)
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1 L-cycloserine, OA and EPA all counteracted PA-induced intracellular ceramide accumulation leading to a downregulation of IL-6 and TNFalpha. Palmitic Acid interleukin 6 Mus musculus
2 In conclusion, PA induced the expression of IL-6 and TNFalpha in N42 neuronal cells independently of TLR4 but, partially, via ceramide synthesis with OA and EPA being anti-inflammatory by decreasing PA-induced intracellular ceramide build-up. Palmitic Acid interleukin 6 Mus musculus