Title : TRH analogue with C-terminal thioamide group: rapid degradation by plasma and its biological effects.

Pub. Date : 1985 Dec

PMID : 3002750






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It was concluded that the substitution of proline amide, for proline thioamide group in TRH molecule did not change binding affinity to receptors in the central nervous system, but decreased biological effectiveness in CNS and substantially decreased the resistance to degradation in human and rat plasma. Proline thyrotropin releasing hormone Rattus norvegicus