Title : Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1,3,4-oxadiazole-2-thione derivatives as potential anticancer agents.

Pub. Date : 2018 Oct

PMID : 30015176






1 Functional Relationships(s)
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1 The SAR study revealed that the substitution of phenyl ring with electron withdrawing group at R1 position and less bulky amines group at R2 position of 1,3,4-oxadiazole-2-thione ring showed significant growth inhibitory activity. Amines sarcosine dehydrogenase Homo sapiens