Title : Purification and characterization of DNA polymerase alpha of Chinese hamster ovary cells.

Pub. Date : 1985 Oct

PMID : 3001502






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Specifically, the enzyme: was sensitive to n-ethylmaleimide and the pol alpha-specific inhibitors, BuPdGTP and aphidicolin; was subject to neutralization by specific monoclonal antibodies raised against human pol alpha; was devoid of detectable 3" to 5" exonuclease activity, and displayed a ribonucleotide-dependent DNA primase activity. Ethylmaleimide DNA polymerase alpha 1, catalytic subunit Homo sapiens
2 Specifically, the enzyme: was sensitive to n-ethylmaleimide and the pol alpha-specific inhibitors, BuPdGTP and aphidicolin; was subject to neutralization by specific monoclonal antibodies raised against human pol alpha; was devoid of detectable 3" to 5" exonuclease activity, and displayed a ribonucleotide-dependent DNA primase activity. Ethylmaleimide DNA polymerase alpha 1, catalytic subunit Homo sapiens