Pub. Date : 2018 Jul
PMID : 30013731
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats. | Capsaicin | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | Results: The data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat. | Capsaicin | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM). | Capsaicin | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats. | Capsaicin | brain-derived neurotrophic factor | Rattus norvegicus |