Title : Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells.

Pub. Date : 2018 Jun

PMID : 30003065






3 Functional Relationships(s)
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1 Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells. dhts mechanistic target of rapamycin kinase Homo sapiens
2 In addition, DHTS downregulated the Akt/mTOR and MAPK signaling pathways. dhts mechanistic target of rapamycin kinase Homo sapiens
3 Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells. dhts mechanistic target of rapamycin kinase Homo sapiens