Title : Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway.

Pub. Date : 2018

PMID : 30002631






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1 Furthermore, the phosphorylation of AMPK induced by ATP in LPS-primed macrophages was significantly suppressed by cyclic stretch, indicating that cyclic stretch negatively regulates IL-1beta secretion through the inhibition of caspase-1 activity by attenuating the AMPK pathway. Adenosine Triphosphate interleukin 1 beta Mus musculus