Title : Mechanisms of Yangjing Capsule in Leydig Cell Apoptosis and Testosterone Synthesis via Promoting StAR Expression.

Pub. Date : 2018 Sep 1

PMID : 29984732






4 Functional Relationships(s)
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1 We observed that the YC can increase the expression of StAR in a dose-dependent manner, and YC can activate the promoter of StAR; moreover, transfection of StAR siRNA can block YC induced anti-apoptotic effects and increased production of testosterone. Testosterone steroidogenic acute regulatory protein Mus musculus
2 We observed that the YC can increase the expression of StAR in a dose-dependent manner, and YC can activate the promoter of StAR; moreover, transfection of StAR siRNA can block YC induced anti-apoptotic effects and increased production of testosterone. Testosterone steroidogenic acute regulatory protein Mus musculus
3 We observed that the YC can increase the expression of StAR in a dose-dependent manner, and YC can activate the promoter of StAR; moreover, transfection of StAR siRNA can block YC induced anti-apoptotic effects and increased production of testosterone. Testosterone steroidogenic acute regulatory protein Mus musculus
4 In conclusion, our results suggested that YC might suppress the apoptosis of MLTC-1 cells and enhance the production of testosterone through regulating the expression of StAR. Testosterone steroidogenic acute regulatory protein Mus musculus