Title : Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures.

Pub. Date : 2018 Jul 5

PMID : 29976873






1 Functional Relationships(s)
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1 Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species. tianeptine interleukin 6 Homo sapiens