Title : An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1).

Pub. Date : 2018 Sep

PMID : 29976562






1 Functional Relationships(s)
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1 Cryoelectron microscopy structural and homology models of MRP1 indicate that the orientation of the Phe583 side chain is altered by ATP binding but are currently unable to provide insights into the molecular mechanism by which this long-range signaling is propagated. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens