Title : Blood urea nitrogen and risk of insulin use among people with diabetes.

Pub. Date : 2018 Sep

PMID : 29974791






8 Functional Relationships(s)
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1 However, whether elevated levels of blood urea nitrogen are associated with increased risk of insulin use among people with diabetes is unknown. Urea insulin Homo sapiens
2 Spline analyses suggested that the relationship between blood urea nitrogen and the risk of insulin use was neutral below blood urea nitrogen level of 25 mg/dL and increased exponentially with blood urea nitrogen levels above 25 mg/dL. Urea insulin Homo sapiens
3 Spline analyses suggested that the relationship between blood urea nitrogen and the risk of insulin use was neutral below blood urea nitrogen level of 25 mg/dL and increased exponentially with blood urea nitrogen levels above 25 mg/dL. Urea insulin Homo sapiens
4 Spline analyses suggested that the relationship between blood urea nitrogen and the risk of insulin use was neutral below blood urea nitrogen level of 25 mg/dL and increased exponentially with blood urea nitrogen levels above 25 mg/dL. Urea insulin Homo sapiens
5 In survival models, compared to those with blood urea nitrogen <= 25 mg/dL, those with blood urea nitrogen > 25 mg/dL had an increased risk of insulin use (hazard ratio = 1.40; confidence interval = 1.30-1.50). Urea insulin Homo sapiens
6 In survival models, compared to those with blood urea nitrogen <= 25 mg/dL, those with blood urea nitrogen > 25 mg/dL had an increased risk of insulin use (hazard ratio = 1.40; confidence interval = 1.30-1.50). Urea insulin Homo sapiens
7 Two-step residual estimation analyses showed that, independent of the impact of estimated glomerular filtration rate, every 10-mg/dL increase in blood urea nitrogen concentration was associated with increased risk of insulin use (hazard ratio = 1.16; confidence interval = 1.12-1.20). Urea insulin Homo sapiens
8 Our results suggest that, among people with diabetes, higher levels of blood urea nitrogen are associated with an increased risk of insulin use. Urea insulin Homo sapiens