Title : Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo.

Pub. Date : 2018 Jul 3

PMID : 29970185






4 Functional Relationships(s)
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1 Azithromycin increased the expressions of DR4, DR5, p62 and LC-3B proteins and potentiated induction of apoptosis by TRAIL. Azithromycin TNF receptor superfamily member 10a Homo sapiens
2 Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo. Azithromycin TNF receptor superfamily member 10a Homo sapiens
3 Knockdown of DR4 and DR5 with siRNAs increased cell survival rate and decreased the expression of cleaved-PARP induced by the combination of azithromycin and TRAIL. Azithromycin TNF receptor superfamily member 10a Homo sapiens
4 CONCLUSION: The synergistic antitumor effect of azithromycin and TRAIL mainly relies on the up-regulations of DR4 and DR5, which in turn result from LC-3B-involved autophagy inhibition. Azithromycin TNF receptor superfamily member 10a Homo sapiens