Title : Human spleen dihydroorotate dehydrogenase: a study of inhibition of the enzyme.

Pub. Date : 1985 Aug

PMID : 2996510






1 Functional Relationships(s)
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1 In addition, three compounds, 5-azaorotate, 5-bromoorotate, and barbiturate were also inhibitory against the two subsequent enzymes of the pathway, orotate phosphoribosyltransferase and orotidylate decarboxylase, so that they could act against three enzymes of the mammalian pyrimidine de novo biosynthetic pathway. pyrimidine uridine monophosphate synthetase Homo sapiens