Pub. Date : 2018 Oct 15
PMID : 29959995
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Our findings suggested that Ori exposure effectively alleviated H2O2-stimulated cytotoxicity, inhibited reactive oxygen species (ROS) generation, and glutathione (GSH) depletion, which were involved in induction of heme oxygenase-1 (HO-1) by enhancing the nuclear factor-erythroid 2-related factor 2 (Nrf2) translocation, decreasing the Keap1 protein expression, and increasing the antioxidant response element (ARE) activity. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Our findings suggested that Ori exposure effectively alleviated H2O2-stimulated cytotoxicity, inhibited reactive oxygen species (ROS) generation, and glutathione (GSH) depletion, which were involved in induction of heme oxygenase-1 (HO-1) by enhancing the nuclear factor-erythroid 2-related factor 2 (Nrf2) translocation, decreasing the Keap1 protein expression, and increasing the antioxidant response element (ARE) activity. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | However, knockdown of Nrf2 and HO-1 with siRNA mostly abolished the cytoprotective effects against H2O2-induced cell oxidative injury, reduced the expression of Nrf2 and HO-1, respectively. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 5 | However, knockdown of Nrf2 and HO-1 with siRNA mostly abolished the cytoprotective effects against H2O2-induced cell oxidative injury, reduced the expression of Nrf2 and HO-1, respectively. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 6 | Taken together, Ori might exhibit a protective role against H2O2-stimulated oxidative damage by the induction of HO-1 expression through the activation of the JNK- and PI3K/AKT-Nrf2 signaling pathways. | Hydrogen Peroxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |