Title : Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells.

Pub. Date : 2018 Sep

PMID : 29956797






1 Functional Relationships(s)
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1 The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells. ursolic acid BCL2 like 1 Homo sapiens