Title : Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease.

Pub. Date : 2018

PMID : 29956204






1 Functional Relationships(s)
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1 In both experimental and human NASH, livers contain cholesterol crystals which are a second signal for NLRP3 activation; this causes interleukin (IL)-1beta and IL18 secretion to attract and activate macrophages and neutrophils. Cholesterol NLR family pyrin domain containing 3 Homo sapiens