Title : 17-(Allylamino)-17-Demethoxygeldanamycin Enhances Etoposide-Induced Cytotoxicity via the Downregulation of Xeroderma Pigmentosum Complementation Group C Expression in Human Lung Squamous Cell Carcinoma Cells.

Pub. Date : 2018

PMID : 29953987






4 Functional Relationships(s)
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1 We found that etoposide increased XPC expression in an AKT activation manner in 2 squamous cell carcinoma H1703 and H520 cells. Etoposide AKT serine/threonine kinase 1 Homo sapiens
2 Knockdown of XPC using siRNA or inactivation of AKT by pharmacological inhibitor PI3K inhibitor (LY294002) enhanced the cytotoxic effects of etoposide. Etoposide AKT serine/threonine kinase 1 Homo sapiens
3 In contrast, enforced expression of XPC cDNA or AKT-CA (a constitutively active form of AKT) reduced the cytotoxicity and cell growth inhibition of etoposide. Etoposide AKT serine/threonine kinase 1 Homo sapiens
4 In contrast, enforced expression of XPC cDNA or AKT-CA (a constitutively active form of AKT) reduced the cytotoxicity and cell growth inhibition of etoposide. Etoposide AKT serine/threonine kinase 1 Homo sapiens