Title : Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking.

Pub. Date : 1985 Jul 2

PMID : 2994715






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Gelsolin is a calcium binding protein that shortens actin filaments. Calcium gelsolin Homo sapiens
2 Once two actin molecules have bound to gelsolin in solutions containing Ca2+, one of the actins remains bound following chelation of calcium, so that the reversal of gelsolin"s effect cannot be accounted for simply by its dissociation from the ends of the shortened filaments to allow for elongation. Calcium gelsolin Homo sapiens
3 The limited reversal of actin-gelsolin binding following removal of calcium and the calcium sensitivity of nucleation by complexes suggest an alternative to reannealing of shortened filaments that involves redistribution of actin monomers and may account for the calcium-sensitive functional reversibility of the solation of actin by gelsolin. Calcium gelsolin Homo sapiens
4 The limited reversal of actin-gelsolin binding following removal of calcium and the calcium sensitivity of nucleation by complexes suggest an alternative to reannealing of shortened filaments that involves redistribution of actin monomers and may account for the calcium-sensitive functional reversibility of the solation of actin by gelsolin. Calcium gelsolin Homo sapiens