Title : Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy.

Pub. Date : 2018

PMID : 29915584






2 Functional Relationships(s)
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1 In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production. 3-methyladenine interleukin 6 Homo sapiens
2 In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production. 3-methyladenine interleukin 6 Homo sapiens