Title : Vaccination with a CD4+ and CD8+ T-cell epitopes-based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity against visceral leishmaniasis.

Pub. Date : 2018 Oct

PMID : 29908151






1 Functional Relationships(s)
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1 In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response. Saponins interferon gamma Mus musculus