Title : Differential effects of oxidizing agents on human plasma alpha 1-proteinase inhibitor and human neutrophil myeloperoxidase.

Pub. Date : 1985 Apr 9

PMID : 2990544






3 Functional Relationships(s)
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Protein Name
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1 Myeloperoxidase can be inactivated by hypochlorous acid, by autoxidation in the presence of H2O2 and C1-, as well as by H2O2 alone. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The tyrosine residue in myeloperoxidase was oxidized only at a relatively high concentration (600 microM) of hypochlorous acid at which point the enzyme simultaneously and completely lost its enzymatic activity. Hypochlorous Acid myeloperoxidase Homo sapiens
3 Loss of activity of myeloperoxidase could also be correlated with the loss of the heme groups present in the enzyme when a relatively high concentration of hypochlorous acid (600 microM) was used and also during autoxidation. Hypochlorous Acid myeloperoxidase Homo sapiens