Title : Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors.

Pub. Date : 1985 Jun 17

PMID : 2989631






1 Functional Relationships(s)
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1 Morphine"s affinity for opioid receptors labeled in vitro with 3H-naloxone or 3H-D-Ala2-D-Leu5-enkephalin was not altered by fluoxetine, which has no affinity for these sites at concentrations as high as 1000 nM. Morphine proenkephalin Rattus norvegicus